Griseofulvin remains useful in paediatric tinea capitis because of its narrow but potent spectrum against dermatophytes. Its fungistatic action results from inhibition of:
- A Mitotic spindle formation through binding tubulin ✓
- B 14 alpha-demethylase
- C Squalene epoxidase
- D Beta-glucan synthase
Correct answer: A. Mitotic spindle formation through binding tubulin
Explanation
Griseofulvin binds fungal microtubular protein and interferes with tubulin polymerisation, arresting metaphase and halting mitosis, so it is fungistatic and active only against dermatophytes. Azoles inhibit 14 alpha-demethylase in ergosterol synthesis, allylamines such as terbinafine inhibit squalene epoxidase, and echinocandins inhibit beta-glucan synthase. Because it is deposited in newly formed keratin, griseofulvin works well for hair and nail infection when given orally with fatty food.
Reference: Katzung's Basic and Clinical Pharmacology, 16th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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