DRESS syndrome is characterised by drug hypersensitivity with systemic organ involvement. The minimum latency period between drug exposure and onset of DRESS is typically:
- A 1–3 days
- B 3–6 months
- C 2–8 weeks ✓
- D More than 6 months
Correct answer: C. 2–8 weeks
Explanation
DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) characteristically has a long latency of 2–8 weeks after initiating the culprit drug—much longer than simple drug eruptions (1–2 weeks) or anaphylaxis (minutes). The prolonged latency reflects the immunological mechanism involving viral reactivation (especially HHV-6) and pharmacological sensitisation. Aromatic anticonvulsants (carbamazepine, phenytoin, phenobarbital) and allopurinol are the commonest culprits.
Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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