Small interfering RNA (siRNA) is used experimentally to silence specific genes. Which molecular complex incorporates the siRNA strand and uses it as a guide to cleave the complementary target mRNA?
- A Spliceosome
- B Ribosome
- C RNA-induced silencing complex ✓
- D Proteasome
Correct answer: C. RNA-induced silencing complex
Explanation
The RNA-induced silencing complex (RISC) incorporates the guide strand of siRNA and uses it to find and cleave complementary target mRNA, silencing gene expression. The spliceosome processes pre-mRNA introns. The ribosome translates mRNA into protein.
Reference: Molecular Biology of the Cell, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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