AMPK (AMP-activated protein kinase) is activated during energy deficit and exerts all of the following effects EXCEPT:

• A Stimulating fatty acid oxidation by inhibiting ACC (acetyl-CoA carboxylase)
• B Stimulating GLUT4 translocation in skeletal muscle
• C Inhibiting cholesterol synthesis by phosphorylating HMG-CoA reductase
• D Activating mTORC1 to increase protein synthesis ✓

Explanation

AMPK is an energy sensor activated by high AMP:ATP ratios; it phosphorylates and inhibits ACC (reducing malonyl-CoA, relieving CPT-I inhibition to increase FAO), promotes GLUT4 translocation, and inhibits anabolic pathways. AMPK phosphorylates and inhibits mTORC1 (not activates), as protein synthesis is energetically expensive and should be suppressed during energy deficit. HMG-CoA reductase inactivation by AMPK reduces cholesterol synthesis.

Reference: Harper's Illustrated Biochemistry, 32nd ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.