Which apolipoprotein serves as the primary structural component of VLDL, IDL, and LDL, and functions as the ligand for the LDL receptor?

• A Apo A-I
• B Apo B-48
• C Apo E
• D Apo B-100 ✓

Explanation

Apo B-100 is synthesized in the liver and is the primary structural apolipoprotein for VLDL, IDL, and LDL. It is the ligand that binds the LDL receptor for cellular uptake. Apo B-48, formed by mRNA editing in the intestine, lacks the receptor-binding domain and is found only on chylomicrons. Apo A-I is the major apolipoprotein of HDL and activates LCAT.

Reference: Harper's Illustrated Biochemistry, 32nd ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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