Which of the following hormones acts via a JAK-STAT signal transduction pathway?

• A Cortisol
• B Glucagon
• C Aldosterone
• D Growth hormone ✓

Explanation

Growth hormone, prolactin, erythropoietin, and cytokines signal through class I cytokine receptors associated with Janus kinases (JAKs). Ligand binding induces receptor dimerisation, activating JAKs which phosphorylate STAT proteins; these dimerize, translocate to the nucleus, and regulate gene transcription. Cortisol and aldosterone use nuclear steroid receptors, while glucagon uses Gs-cAMP–PKA.

Reference: Harper's Illustrated Biochemistry, 32nd ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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