Which receptor type is characterized by intrinsic guanylyl cyclase activity and uses cGMP as its second messenger?

• A TSH receptor
• B Cortisol receptor
• C ANP (atrial natriuretic peptide) receptor ✓
• D Growth hormone receptor

Explanation

ANP (atrial natriuretic peptide) receptor is a membrane receptor with intrinsic guanylyl cyclase activity in its cytoplasmic domain. ANP binding directly activates this enzyme, generating cGMP from GTP. Elevated cGMP activates PKG (protein kinase G), leading to natriuresis and vasodilation. TSH receptor is Gs-coupled (cAMP); cortisol receptor is an intracellular nuclear receptor; GH receptor uses JAK2/STAT signaling.

Reference: Harper's Illustrated Biochemistry, 32nd ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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