Atrial natriuretic peptide lowers blood pressure by acting on vascular smooth muscle and the kidney. Its receptor differs from the adrenergic receptors because it:

• A Is coupled to Gq and raises intracellular calcium
• B Has an intracellular catalytic guanylyl cyclase domain that generates cGMP ✓
• C Phosphorylates STAT3 through associated JAK1
• D Inhibits adenylate cyclase through Gi

Explanation

The ANP receptor (NPR-A) is a single-pass transmembrane protein with an extracellular ligand-binding domain and an intracellular guanylyl cyclase catalytic domain. Ligand binding directly activates cGMP production without any G-protein intermediate; cGMP then activates PKG, causing vasorelaxation and natriuresis. This places ANP in the same catalytic-receptor family as the nitric oxide soluble guanylyl cyclase system, but as a membrane-bound rather than cytosolic enzyme.

Reference: Ganong's Review of Medical Physiology, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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