Which vitamin is the precursor of the cofactor pyridoxal phosphate, required for the activity of delta-aminolevulinic acid synthase?

• A Vitamin B12 (cobalamin)
• B Vitamin B6 (pyridoxine) ✓
• C Vitamin B2 (riboflavin)
• D Vitamin B3 (niacin)

Explanation

Pyridoxal phosphate (PLP), the active form of vitamin A6, is an essential cofactor for ALAS. PLP forms a Schiff base with the glycine substrate, enabling condensation with succinyl-CoA. This is a classic biochemistry fact linking a vitamin deficiency to impaired heme synthesis.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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