A research study measures serum levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) as markers of oxidative damage. These compounds are produced during which process?

• A Protein glycation
• B Uric acid catabolism
• C Oxidative deamination of amino acids
• D Lipid peroxidation of polyunsaturated fatty acids ✓

Explanation

Malondialdehyde and 4-hydroxynonenal are aldehydic breakdown products formed when polyunsaturated fatty acids in membranes undergo lipid peroxidation. They diffuse from the membrane, adduct proteins and DNA, and serve as measurable markers of oxidative injury. Glycation produces advanced glycation end-products, and oxidative deamination yields ammonia and alpha-keto acids, neither of which releases these aldehydes.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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