Hydrogen peroxide generated inside peroxisomes during fatty acid oxidation is detoxified locally by which enzyme?

• A Glutathione peroxidase
• B Myeloperoxidase
• C Superoxide dismutase
• D Catalase ✓

Explanation

Catalase is located predominantly in peroxisomes, where it decomposes the hydrogen peroxide produced by oxidases such as B-amino acid oxidase and the flavoprotein dehydrogenases of very long chain fatty acid beta-oxidation. It catalyses 2H2O2 to 2H2O plus O2. Glutathione peroxidase handles H2O2 in cytosol and mitochondria but depends on GSH supply, which is why it is not the local peroxisomal defence. Myeloperoxidase is confined to neutrophil granules.

Reference: Harper's Illustrated Biochemistry, 32nd ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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