5'-Nucleotidase elevation alongside ALP is used clinically to confirm:
- A The ALP elevation is of hepatic (biliary) origin ✓
- B The ALP elevation is of bone origin
- C The ALP elevation is of placental origin
- D The ALP elevation is of intestinal origin
Correct answer: A. The ALP elevation is of hepatic (biliary) origin
Explanation
5'-Nucleotidase is a liver-specific enzyme that co-elevates with ALP in hepatic/biliary disease but does not rise in bone, placental, or intestinal causes of ALP elevation. GGT serves a similar discriminating role. This differentiation is critical because ALP alone cannot indicate its tissue source without an isoenzyme study or a co-marker.
Reference: Harper's Illustrated Biochemistry, 32nd ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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