Different GLUT transporters exhibit tissue-specific expression and distinct kinetic properties. Which GLUT isoform is insulin-dependent and mediates glucose uptake in skeletal muscle and adipose tissue?
- A GLUT4 ✓
- B GLUT2
- C GLUT3
- D GLUT1
Correct answer: A. GLUT4
Explanation
GLUT4 is insulin-responsive and translocates to the plasma membrane of skeletal muscle and adipose tissue upon insulin stimulation. GLUT1 and GLUT3 are constitutive, high-affinity transporters in brain and erythrocytes. GLUT2 is the low-affinity transporter in liver and pancreatic beta cells. This distinction is frequently tested in diabetes and hypoglycemia contexts.
Reference: Ganong's Review of Medical Physiology, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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