Glucose-6-phosphate dehydrogenase (G6PD) deficiency renders RBCs unable to maintain adequate NADPH levels. Which of the following drugs is SAFE to use in G6PD-deficient patients?
- A Primaquine
- B Ceftriaxone ✓
- C Dapsone
- D Nalidixic acid
Explanation
G6PD deficiency impairs the HMP shunt's NADPH production, reducing glutathione regeneration and rendering RBCs susceptible to oxidative hemolysis. Drugs causing hemolysis in G6PD deficiency include: primaquine, dapsone, nalidixic acid, nitrofurantoin, methylene blue, and high-dose aspirin. Ceftriaxone (a 3rd generation cephalosporin) does not generate oxidative stress and is safe in G6PD deficiency. Key triggers to remember: 8-aminoquinolines (primaquine), sulfones (dapsone), quinolones (nalidixic acid), and oxidant foods (fava beans). Infections themselves can also precipitate hemolysis.
Reference: Harper's Illustrated Biochemistry, 32nd ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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