Which tumour marker combination is most specific for monitoring response to treatment in a patient with epithelial ovarian cancer?
- A AFP + beta-hCG
- B CA-125 + HE4 (ROMA score) ✓
- C CEA + CA 19-9
- D PSA + PAP
Correct answer: B. CA-125 + HE4 (ROMA score)
Explanation
CA-125 is the primary marker for epithelial ovarian cancer monitoring; HE4 (human epididymis protein 4) combined with CA-125 as the ROMA (Risk of Ovarian Malignancy Algorithm) score improves specificity. AFP + beta-hCG is for germ cell tumours. CEA + CA 19-9 is used for colorectal/pancreatic cancers. PSA + PAP is for prostate cancer.
Reference: Harper's Illustrated Biochemistry, 32nd ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.