Anatomy · Pelvis, Perineum and Reproductive Anatomy

Prostatic carcinoma most commonly arises from which anatomical zone of the prostate?

  • A Peripheral zone
  • B Central zone
  • C Transition zone
  • D Anterior fibromuscular stroma
Correct answer: A. Peripheral zone

Explanation

The peripheral zone constitutes 70 percent of the prostatic glandular tissue and is the site where 70 percent of prostate carcinomas arise. The transition zone is the site of benign prostatic hyperplasia. The central zone rarely develops carcinoma. The anterior fibromuscular stroma is non-glandular and not a site of carcinoma.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

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