Which zone of the prostate gives origin to most cases of benign prostatic hyperplasia?

• A Peripheral zone
• B Central zone
• C Transition zone ✓
• D Anterior fibromuscular stroma

Explanation

Benign prostatic hyperplasia arises in the transition zone surrounding the proximal urethra, producing urinary obstruction early. Carcinoma of the prostate arises predominantly in the peripheral zone, palpable on digital rectal examination, which is why option A tempts students but is wrong here. The central zone is rarely involved by either disease, and the anterior fibromuscular stroma is gland-free.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.