Which antiemetic carries a regulatory boxed warning for dose-dependent QT prolongation and torsades de pointes, limiting its use in susceptible patients?
- A Dimenhydrinate
- B Droperidol ✓
- C Scopolamine
- D Aprepitant
Correct answer: B. Droperidol
Explanation
Droperidol carries a boxed warning for QT prolongation and fatal arrhythmias, so an ECG is advised before dosing and it should be avoided in patients with known prolonged QT or on QT-prolonging drugs. At prophylactic doses it remains effective and widely used. Scopolamine causes sedation, dry mouth and central anticholinergic effects, while aprepitant's main issues are fatigue and CYP3A4 interactions.
Reference: Katzung's Basic and Clinical Pharmacology, 16th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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