Match the pharmacological determinant with its clinical correlate: which pairing is correct?
- A Lipid solubility determines duration of action
- B Lipid solubility determines intrinsic potency ✓
- C Protein binding determines potency
- D pKa determines duration of action
Correct answer: B. Lipid solubility determines intrinsic potency
Explanation
Potency parallels lipid solubility because a highly lipophilic drug partitions readily into nerve membranes where its receptor sits. Duration parallels protein binding: bupivacaine is roughly 95 percent bound and lasts long, while chloroprocaine is minimally bound and very short acting. Onset relates inversely to pKa. Mixing up these three pairings is a classic examination trap and each distractor here represents one such swap.
Reference: Katzung's Basic and Clinical Pharmacology, 16th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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