Compound A (hexafluoroisopropanol) formed during sevoflurane degradation is rendered non-toxic by which hepatic process?

• A Oxidative dehalogenation by CYP2E1
• B Reduction by cytochrome P450 reductase
• C Glucuronide conjugation ✓
• D Acetylation by N-acetyltransferase

Explanation

Hexafluoroisopropanol (HFIP), the primary metabolite of sevoflurane, is rapidly glucuronide-conjugated by hepatic UDP-glucuronosyltransferase and excreted renally. This reaction prevents bioactivation to toxic intermediates, explaining sevoflurane's excellent hepatic safety profile. CYP2E1 oxidation is the initial step generating HFIP, not the detoxification step. Halothane's toxicity arises specifically because its metabolites are not safely conjugated.

Reference: Morgan & Mikhail's Clinical Anesthesiology, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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