During inhalational induction with sevoflurane in a closed-circuit system, compound A (fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether) is generated. The primary concern with Compound A is:
- A Myocardial sensitization to catecholamines
- B Malignant hyperthermia trigger
- C Nephrotoxicity from renal tubular injury ✓
- D Diffusion hypoxia
Correct answer: C. Nephrotoxicity from renal tubular injury
Explanation
Compound A is a vinyl ether degradation product of sevoflurane formed when it contacts soda lime or baralyme at high temperatures in low-flow or closed circuits. In animal models, Compound A causes proximal renal tubular necrosis. Although clinical nephrotoxicity in humans remains controversial, fresh gas flow rates of at least 2 L/min are recommended when sevoflurane is used to limit Compound A accumulation.
Reference: Morgan & Mikhail's Clinical Anesthesiology, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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